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语言下和口腔传递过敏原:针对口腔树突细胞进行过敏原特异性免疫疗法

Zhen Wang¹, Wenyan Yu¹, Huilin Xu¹

¹Department of Pharmacy, Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing 314000, China.

Journal of controlled release : official journal of the Controlled Release Society

|March 11, 2026

概括

语言下免疫疗法 (SLIT) 提供了一个无针的过敏治疗替代方案. 通过辅助剂或纳米颗粒物增强对口腔树突细胞 (DC) 的过敏原传递,可以提高SLIT的有效性并减少所需的过敏原剂量.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
药物输送系统药物输送系统

背景情况:

皮下免疫疗法 (SCIT) 涉及重复注射,并带有风险.
舌下免疫疗法 (SLIT) 是一种更安全,无针的替代方法来治疗过敏.
目前的SLIT需要比SCIT更高的过敏原剂量,因为缺乏辅助剂或专门的输送.

研究的目的:

审查影响亚语言/口腔过敏原输送的生理因素.
检查已批准的SLIT配方的治疗机制和临床开发.
为提高SLIT疗效,对辅助剂和输送系统进行分类.

主要方法:

对生理因素,机制和临床数据的文献综述.
对助剂和传递系统进行过敏原呈现的分析.
自然和合成产品的分类,用于下舌/口服.

主要成果:

语言下/口腔路线为局部和全身药物输送提供了优势.
辅助剂和输送系统可以提高过敏原对口腔树突细胞 (DC) 的可用性.
针对口服DCs可能会增加过敏原特异性免疫疗法 (AIT) 的有效性,同时减少剂量.

结论:

优化过敏原呈现平台是改善SLIT的关键.
辅助剂和传送系统,如纳米颗粒物,对AIT有希望.
对这些平台的进一步研究可能会导致更有效,更安全的过敏治疗方法.

关键词:

空气过敏原和食物过敏原.过敏原呈现平台的平台.过敏原特异性免疫疗法舌下和口腔的粘膜.准的是口腔树突细胞.

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