在患有阻塞性睡眠呼吸暂停的患者中,尿路IgM分泌增加
Abderrahim Oulhaj1, Omran Bakoush2, Moien A B Khan3
1Department of Public Health and Epidemiology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.
阻塞性睡眠呼吸暂停 (OSA) 与非糖尿病患者的损伤有关,尿液IgM和白蛋白表明这一点. 这些标记物可以作为OSA患者球损伤的早期指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 睡眠医学 睡眠医学
- 心血管研究研究心血管研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与间歇性低氧化症有关,可能导致内皮损伤.
- 在OSA患者的尿液免疫球蛋白M (IgM-尿液) 上存在有限的证据.
- 这项研究调查了糖尿病和非糖尿病个体中OSA严重程度与尿路IgM和白血病之间的联系.
研究的目的:
- 评估阻塞性睡眠呼吸暂停严重程度与尿路IgM和白尿之间的关联.
- 为了比较非糖尿病患者和糖尿病患者的这些关联.
主要方法:
- 一项涉及124名接受过多睡眠图的成年人的横截面研究.
- 尿样分析了IgM和白蛋白,并将其正常化为肌素.
- 使用多变量线性回归模型,对混因素进行调整,并测试与糖尿病状态的相互作用.
主要成果:
- 在非糖尿病参与者中,降低平均SPO2和增加氧气脱度指数和呼吸暂停-呼吸暂停指数与更高的泌尿IgM尿和白尿显著相关.
- 这些关联在糖尿病患者中没有显著意义.
- 尿液IgM和白蛋白与非糖尿病患者的OSA严重程度相关.
结论:
- 尿液IgM和白蛋白水平与非糖尿病人的OSA严重程度有关.
- 这些标记物可以作为睡眠呼吸暂停中球损伤的具有成本效益的非侵入性生物标记物.
- 需要进一步的纵向研究来确认OSA治疗的可逆性.
更多相关视频
04:53Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
Published on: October 18, 2024
07:54Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
相关概念视频
Sleep Apnea
The condition is more prevalent among...
Urine Studies I: Urinalysis
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
Drugs Used in Upper Respiratory Disorders: Overview
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
