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早期COPD的定义和疾病进展的预测因素:系统性审查

Alastair Watson^1,2, Ross Davidson^3,2, Fu Chuen Kon⁴

¹School of Clinical Medicine, University of Cambridge, Cambridge, UK Alastair.watson7@nhs.net.

European respiratory review : an official journal of the European Respiratory Society

|March 11, 2026

概括

迫切需要就早期慢性阻塞性肺病 (COPD) 的定义达成共识. 识别COPD进展的预测因素可以使早期的,有针对性的治疗策略能够改善患者的治疗结果.

科学领域:

肺部医学肺部医学
呼吸系统研究呼吸系统研究
临床流行病学临床流行病学

背景情况:

早期慢性阻塞性肺病 (COPD) 代表了疾病的初始阶段.
不一致的术语和定义阻碍了早期的COPD研究和临床应用.
标准化定义对于推进研究和患者护理至关重要.

研究的目的:

系统地审查早期COPD的临床研究.
分析早期COPD使用的术语和定义.
评估早期COPD疾病进展的预测因素.

主要方法:

使用标准化协议对早期COPD的临床研究进行系统查.
两个独立的评论员评估了标题,摘要和全文文章.
通过修改的唐斯和黑名单来评估研究质量.

主要成果:

识别的术语:PRISM,GOLD 0,早期的COPD,有风险的COPD和COPD前期.
发现了多样化的定义;提议的早期COPD定义并没有经常使用.
进展的关键预测因素包括年龄,吸烟史,症状,肺功能和CT指标.

结论:

迫切需要就早期COPD的临床适用定义达成共识.
进展的预测者需要在早期患者分层时进行验证.
有针对性的管理策略对于阻止或改变COPD进展至关重要.

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