相关实验视频

Updated: Mar 13, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

肺移植中的抗HLA抗体:诊断陷和未来方向

Andrea Zajacova^1,2, Eva Revilla-Lopez³, Miray Guney⁴

¹University Hospitals Leuven, Department of Respiratory Diseases, Leuven, Belgium andrea.zajacova@kuleuven.be.

European respiratory review : an official journal of the European Respiratory Society

|March 11, 2026

概括

捐赠者特定的抗人类白细胞抗原 (HLA) 抗体 (DSA) 是肺移植排斥的关键. 目前的检测方法是不一致的,突出需要先进的类型和功能测试,以更好地评估风险.

科学领域:

免疫学免疫学免疫学
移植科学移植科学
临床诊断临床诊断临床诊断

背景情况:

肺移植接受者经历高排斥率,影响长期结果.
捐赠者特异性抗人类白细胞抗原 (HLA) 抗体 (DSA) 是肺部全移植中抗体中介排斥的主要媒介.
在整个移植过程中,DSAs的确切作用,检测和解释仍然不清楚.

研究的目的:

审查目前对肺移植中DSAs的理解.
突出现有的HLA类型和抗体检测方法的局限性.
探索先进免疫学试验的潜力,以改善临床实践.

主要方法:

关于HLA抗体生物学和检测的当前文献的综述.
对标准HLA类型和抗体监测试验的局限性进行分析.
讨论新兴的功能性试验及其潜在的临床实用性.

主要成果:

低分辨率的HLA类型可能会错误地分类不匹配和DSA.
标准测试中的光强度中位数缺乏关于抗体功能的信息 (亲和力,热情性).
功能性测试提供了更深入的见解,但不经常使用.

结论:

不一致的DSA检测和解释阻碍了肺移植排斥的有效管理.
高分辨率的HLA类型和功能测试显示了改善风险分层的前景.
需要进一步的研究,以将先进的免疫学工具纳入肺移植的临床实践.

更多相关视频

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

相关概念视频

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...