根据阿尔茨海默病的病理生理学,认知表现和神经解剖学的差异
Isadora Cristina Ribeiro1, Brenda Costa Gonçalves1, Ítalo Karmann Aventurato1
1Universidade Estadual de Campinas, Instituto Brasileiro de Neurociências e Neurotecnologia, Departamento de Neurologia, Campinas SP, Brazil.
Arquivos de neuro-psiquiatria
|March 11, 2026
概括
认知功能在由Amyloid,Tau和神经退行 (AT(N)) 分类定义的先发性痴呆阶段之间有所不同. 记忆与阿尔茨海默病连续组中的大脑结构有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 痴呆前期阶段意味着痴呆风险增加.
- 粉样蛋白,和神经退行 (AT(N)) 分类基于阿尔茨海默病 (AD) 病理生理学的风险分层.
- 在先发性病阶段的认知和解剖学特征需要进一步了解.
研究的目的:
- 为了比较AT(N) 组中先发性病患者的临床和解剖学概况.
- 为了检查AT (N) 组内认知和大脑结构 (皮层厚度,皮层下体积) 之间的关联.
主要方法:
- 72名患有主观认知衰退或轻度认知障碍的老年人使用AT(N) 标准进行了分类.
- 参与者接受了认知测试,磁共振成像 (MRI) 和脑脊液 (CSF) 分析.
- 使用了多变量,单变量和线性回归分析.
主要成果:
- 与AD连续和正常生物标志物组相比,疑似非AD病理生理组表现出较差的注意力/执行功能 (p=0.04).
- 在AT(N) 分类组之间没有观察到皮层厚度的显著差异 (p>0.05).
- 在AD连续组中,记忆性能与左状回环厚度相关 (p<0.001,r=0.238).
结论:
- 认知功能,而不是灰色质量指标,在先发性痴呆症中的AT (N) 分类组之间存在显著差异.
- 记忆与AD连续体 (阳性粉样β) 内的个体的皮质厚度有关.
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