含有可共聚合四级氨基基基抗微生物单体的组织修复剂的特性和性能评估
Sowmya Rao1, Vidya Pai2, Ashwini Prabhu3
1Department of Dental Materials, Yenepoya Dental College, Yenepoya (Deemed to be University).
Dental materials journal
|March 11, 2026
概括
用四级盐 (QAS) 改性组织修复剂 (TC) 显示微生物粘附性降低和良好的细胞相容性. 这些抗微生物牙科材料保持了机械性能,为口腔应用提供了有前途的替代品.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 抗菌剂 抗菌剂 抗菌剂
背景情况:
- 组织调节剂 (TC) 在牙科中使用,但可能易受微生物殖民.
- 四级盐 (QAS) 具有已知的抗菌性质.
研究的目的:
- 通过整合QAS (DHMAI和DDMAI) 来修改商用TC.
- 评估修改TC的抗菌活性,细胞毒性和机械性质.
主要方法:
- 根据MIC和MBC将DHMAI和DDMAI纳入TC.
- 使用FTIR进行表征,对S. mutans,S. aureus,C. albicans进行抗菌检测,对细胞毒性进行MTT检测,并测试机械性质.
主要成果:
- 修改后的TC显示微生物粘附性显著降低.
- 细胞毒性测定显示了与L-929纤维细胞的良好细胞相容性.
- 机械和物理性能与对照TC保持相似.
结论:
- 经QAS修改的TC对常见的口腔微生物表现出有效的抗菌活性.
- 改性材料具有细胞相容性,并保持了基本的机械完整性.
- 这种增强的TC为改善口腔卫生和防止生物膜形成提供了可行的选择.
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