不完整的热除加速局部和全身瘤进展在一个免疫能力强的前列腺癌模型
Avan Kader1, Marie-Luise Helene Hildegard Ranner-Hafferl2, Anna-Lena Polz2
1Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, TUM University Hospital, Munich, Germany.
概括
在小鼠中,微致命热处理 (iTA) 意外地加速了前列腺癌的局部和全身增长. 这突出了需要仔细评估风险和监测后热除,以防止瘤的进展.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 前列腺癌残留瘤需要有效的治疗策略.
- 亚致性高温症对残留瘤的影响尚未完全理解.
- 具有免疫能力的小鼠模型对于评估癌症疗法至关重要.
研究的目的:
- 为了评估亚致死性高温症对前列腺残留瘤的影响.
- 为了研究不完整热除 (iTA) 对瘤生长的影响.
- 分析iTA引起的分子和免疫变化.
主要方法:
- 在体外研究Myc-CaP细胞生长.
- 在活体中评估FVB小鼠的瘤生长 (n=84).
- 蛋白质组分析,免疫组织化学和残留瘤的西部斑.
主要成果:
- 在体外,亚致命热增加了Myc-CaP细胞的发光.
- 在体内,iTA显著增强了局部和全身的瘤生长.
- iTA诱导的前瘤原因子 (IL-6,HGF,VEGF) 和骨髓细胞透.
结论:
- 不完整的热除可以加速瘤的进展.
- iTA触发了一种促炎,促生长的瘤微环境.
- 治疗前风险评估和剥离后监测是必不可少的.
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