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瘤免疫微环境的治疗诱导的重塑:免疫治疗的机制见解和影响

Dongping Chen¹, Ruiqi Wu¹, Zhengyu Liu^1,2

¹Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.

Chinese medical journal

|March 12, 2026

概括

疗法显著改变瘤免疫微环境 (TIME),影响治疗的有效性. 了解这些变化,使用先进的技术,是优化癌症免疫疗法和预测患者结果的关键.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

瘤免疫微环境 (TIME) 对癌症的进展和对治疗的反应至关重要.
治疗干预动态重塑时间,影响治疗疗效.
先进的技术为TIME-主机-治疗相互作用提供了新的见解.

研究的目的:

审查疗法如何重塑时间.
阐明将 TIME 变化与免疫疗法反应联系起来的机制.
讨论优化组合治疗的策略.

主要方法:

关于治疗诱导的时间变化的当前文献的综述.
分析多omics数据 (例如,单细胞测序,空间转录学).
整合了关于TIME重塑和免疫治疗结果的发现.

主要成果:

疗法在TIME的细胞和分子组成中引发了显著的动态变化.
这些变化极大地调节了免疫疗法的有效性.
新兴技术为这些复杂的相互作用提供了高分辨率的视图.

结论:

了解治疗驱动的TIME重塑对于预测治疗反应至关重要.
高分辨率技术能够精确监测和预测治疗疗效.
这些知识将指导个性化组合治疗策略的开发.

关键词:

免疫检查站封锁免疫检查站封锁免疫微环境是一个微环境.免疫疗法耐药性免疫疗法耐药性瘤治疗疗法瘤治疗瘤免疫相互作用

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