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Updated: Mar 13, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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瘤特定的HORMAD1表达扰乱了线粒体的停止,并驱动了对线粒体激酶抑制剂的敏感性

Callum Walker1, Gabriel Kollarovic1, Daniel Weekes1

  • 1The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

Nature communications
|March 12, 2026
PubMed
概括

在癌细胞中异常的HORMAD1表达破坏了线粒分裂,导致基因组不稳定. 这一发现揭示了三阴性乳腺癌 (TNBC) 的新治疗点,通过利用癌细胞分裂中的漏洞.

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