相关实验视频

Updated: Mar 13, 2026

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

18.2K

来自不同同核素病变的α-synuclein纤维状多态体的结构-功能关系.

Tetiana Serdiuk1, Virginie Redeker2, Jimmy Savistchenko2

  • 1Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.

Molecular systems biology
|March 12, 2026
PubMed
概括

致病性α-synuclein (αSyn) 结构在像帕金森病 (PD) ,勒维体痴呆症 (DLB) 和多个系统缩 (MSA) 这样的synucleinopathies中有所不同. 这些结构变异影响蛋白质相互作用和细胞反应,提供新的治疗点.

关键词:
阿尔法-协同核蛋白是一种粉样蛋白菌株的一种.有限蛋白质分解 - 与质谱学相结合帕金森氏症 帕金森氏症结构蛋白质组学 结构蛋白质组学

更多相关视频

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo09:44

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo

Published on: June 2, 2019

22.8K
Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons10:03

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

11.4K

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.5K
Amyloid Fibrils03:03

Amyloid Fibrils

6.9K
Protein Folding01:22

Protein Folding

Overview
129.7K
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
12.0K
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
91.1K
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
48.1K