Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

9.3K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
9.3K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

3.2K
3.2K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

2.8K
2.8K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.8K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.8K
Understanding Memory01:19

Understanding Memory

1.7K
Memory is the retention of information or experiences over time, facilitated through three main processes: encoding, storage, and retrieval. Encoding is the process of inputting information into the memory system. For instance, when listening to a lecture, watching a play, reading a book, or having a conversation, the brain is actively encoding information. This initial stage involves transforming sensory input into a form that can be processed and stored by the brain. Various factors, such as...
1.7K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

9.0K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
9.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The telomerase/shelterin system is impaired in acromegaly and Cushing´s disease: Potential pathophysiological relevance.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

PKMζ-PKCι/λ double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory.

bioRxiv : the preprint server for biology·2026
Same author

PKMζ-KIBRA interactions, molecular turnover, and memory.

bioRxiv : the preprint server for biology·2026
Same author

Maintenance of memory by negative feedback of synaptic protein elimination: modeling KIBRA-PKMζ dynamics in LTP.

Learning & memory (Cold Spring Harbor, N.Y.)·2025
Same author

Obesity duration is linked to bariatric surgery outcomes via adipose tissue response.

The Journal of endocrinology·2025
Same author

Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets.

Acta neuropathologica communications·2025

相关实验视频

Updated: Mar 13, 2026

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
10:05

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

Published on: March 5, 2019

6.9K

PKMζ-KIBRA相互作用,分子循环和记忆

Changchi Hsieh1, David A Cano2, Panayiotis Tsokas1,3,4

  • 1Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Health Sciences University, Brooklyn, NY, 11203, USA.

Molecular brain
|March 12, 2026
PubMed
概括

持久的KIBRA-PKMζ寡合体通过克服分子周转来维持长期记忆. 这些分子结构的持续形成确保了尽管单个蛋白质成分的降解,记忆的巩固.

关键词:
在PKM-zeta中.在PKMzetazeta中使用.在WWC1中,WWC1是WWC1的第一个版本.长期增强 (LTP) 的作用.

更多相关视频

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy
10:41

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy

Published on: June 7, 2019

9.1K
Assessment of Social Interaction Behaviors
06:41

Assessment of Social Interaction Behaviors

Published on: February 25, 2011

95.6K

相关实验视频

Last Updated: Mar 13, 2026

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
10:05

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

Published on: March 5, 2019

6.9K
Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy
10:41

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy

Published on: June 7, 2019

9.1K
Assessment of Social Interaction Behaviors
06:41

Assessment of Social Interaction Behaviors

Published on: February 25, 2011

95.6K

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 结构生物学 结构生物学

背景情况:

  • 基布拉和PKMζ之间持续的相互作用对于保持突触可塑性和长期记忆至关重要.
  • 基布拉和PKMζ的分子周转对记忆的持久性构成了挑战,超出了它们的个体寿命.

研究的目的:

  • 调查KIBRA-PKMζ相互作用的结构基础及其在克服记忆维护分子周转的作用.
  • 阐明KIBRA-PKMζ寡合体是如何促进持续记忆巩固的.

主要方法:

  • 利用AlphaFold 3来预测KIBRA-PKMζ异构体和异构体的结构.
  • 研究了KIBRA-PKMζ相互作用抑制剂 (K-ZAP和 ζ-stat) 的作用机制.
  • 评估了抑制剂对已建立的晚期LTP和长期空间记忆的影响.

主要成果:

  • 预测的结构揭示了K-ZAP阻断异构体的形成, ζ-stat阻止更大的寡合结构的组装.
  • 无论是K-ZAP还是z-stat都破坏了1个月的空间记忆,这表明了寡合体形成的重要性.
  • 持续的KIBRA-PKMζ寡合化对于克服分子循环和维持记忆至关重要.

结论:

  • 持续形成KIBRA-PKMζ寡合体是长期记忆持久性的基本分子机制.
  • 对KIBRA-PKMζ相互作用的结构洞察力为了解记忆巩固和潜在的治疗目标提供了基础.