使用世卫组织报告系统分类肝细胞学:机构经验和恶性瘤风险评估
Saroja Devi Geetha1, Amr Ali1, Meena Kashi1
1Department of Pathology and Laboratory Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, New Hyde Park, New York, USA.
Diagnostic cytopathology
|March 12, 2026
概括
本研究使用世界卫生组织 (WHO) 系统重新分类肝细胞学报告,为每个类别确定恶性瘤 (ROM) 风险. 对于非诊断性和非典型的肝细胞学发现,建议重复采样.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 肝细胞病理学的标准化报告对于准确的患者管理至关重要.
- 世界卫生组织 (WHO) 肝细胞病理报告系统为一致的沟通提供了一个框架.
- 在细胞病理学类别中评估恶性瘤 (ROM) 的风险对于临床决策至关重要.
研究的目的:
- 根据世卫组织分类系统重新分类肝细胞学报告.
- 确定与世卫组织肝细胞病理学分类的每个类别相关的恶性瘤 (ROM) 风险.
- 评估重复细针吸收 (FNA) 在特定诊断类别中的实用性.
主要方法:
- 追溯审查976个肝细胞学报告从2019年至2023年.
- 根据世卫组织分类系统重新分类细胞学诊断.
- 分析手术后续 (SFU) 数据,以确定恶性瘤 (ROM) 的风险.
主要成果:
- 世卫组织的分类产生了包括非诊断性 (n=79),良性 (n=117),不典型 (n=25),可疑恶性瘤 (n=6) 和恶性瘤 (n=749) 的类别.
- 恶性瘤 (ROM) 的风险为非诊断的17%,良性的23%,以及基于SFU的非典型,可疑和恶性类别的100%.
- 重复FNA显示高恶性升级率:非诊断类别的80%和非典型类别的75%.
结论:
- 这项研究为世卫组织肝细胞病理报告系统类别提供了ROM值.
- 建议对非诊断性和非典型的肝细胞学发现进行重复采样,因为恶性恶性升级率显著.
- 世卫组织的分类系统有助于对恶性瘤风险进行分层,并指导肝病变的临床管理.
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