维生素D和膀癌风险:一个总体审查和第二阶段元分析
Stefano Mancin1, Gaetano Ferrara2, Sara Morales Palomares3
1IRCCS Humanitas Research Hospital, Milan, Italy.
Cancer medicine
|March 12, 2026
概括
低维生素D水平与更高的膀癌风险有关. 维持足够的血清维生素D可能会提供保护,但通过饮食摄入的证据是不确定的.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 膀癌是一种普遍存在的恶性瘤,复发率很高.
- 维生素D因骨健康而闻名,因其在癌症风险 (包括膀癌) 中的潜在作用而受到越来越多的研究.
研究的目的:
- 评估血清维生素D水平,饮食维生素D摄入量和补充剂与膀癌风险之间的关系.
主要方法:
- 一项综合性审查综合了关于维生素D和膀癌的系统审查和元分析的发现.
- 包括的研究重点是血清维生素D水平或饮食摄入量.
- 使用JBI批判性评估工具评估质量;定量综合涉及两个二级元分析.
主要成果:
- 血清维生素D水平低 (低于30nmol/L) 与膀癌风险增加显著相关 (RR=1.32).
- 较高的血清维生素D水平表明风险没有显著降低 (RR=0.86).
- 关于饮食维生素D摄入量的数据提供了不一致的结果,有迹象表明温和的保护作用.
结论:
- 血清维生素D的低水平始终与更高的膀癌风险有关.
- 保持血清维生素D水平高于30nmol/L可能会提供保护性益处.
- 需要进一步的研究来澄清饮食摄入量,补充剂和标准化测量方法的作用.
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