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Updated: Mar 13, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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扩大本佐克萨博林基架对碳酸无水的抑制潜力:合成,结构特征和体外抗瘤活性

Gioele Renzi1, Lorenzo Masoni1, Fabrizio Carta1

  • 1NEUROFARBA Department, Sezione di Scienze Farmaceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy.

Journal of medicinal chemistry
|March 12, 2026
PubMed
概括

研究人员开发了新型的2H-糖胺素作为碳酸酶 (CA) 抑制剂. 几种化合物表现出低纳米分子活性,其中一种衍生物对癌细胞表现出强大的抗增殖作用.

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All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
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