针对基于免疫代谢的透瘤调节性T细胞
Na Li1, Dexue Tian2
1Zhejiang Chinese Medical University, Hangzhou 310053, China.
Cancer biology & medicine
|March 12, 2026
概括
免疫检查点抑制剂 (ICI) 可以通过促进调节性T细胞 (Tregs) 而失败. 准Treg代谢提供了一个精确的策略,以增强癌症免疫疗法,没有系统副作用.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 代谢重编程 代谢重编程
背景情况:
- 免疫检查点阻塞 (ICB) 重新激活CD8+T细胞,但可以受到调节性T细胞 (Tregs) 的阻碍.
- 免疫检查点抑制剂 (ICI) 无意中增强Treg免疫抑制活性,原因是检查点分子在Treg和常规T细胞上的共同表达.
- 传统的Treg减肥策略会导致系统性自身免疫的风险.
研究的目的:
- 探索瘤透Tregs (TI-Tregs) 和瘤微环境 (TME) 之间的相互作用.
- 为了阐明TI-Tregs中的代谢重编程.
- 确定TI-Tregs的高选择性标,以提高免疫治疗的有效性和安全性.
主要方法:
- 审查关于免疫检查点,Tregs和TME相互作用的当前文献.
- 分析TI-Tregs使用的代谢途径.
- 针对TI-Tregs的向代谢干预措施的概念化.
主要成果:
- 在TI-Tregs和Tconvs上免疫检查点的同时表达导致ICI的意外Treg激活.
- 代谢重编程是TI-Tregs在TME中的一个关键特征.
- 准TI-Treg代谢是一个有希望的选择性免疫调节策略.
结论:
- 选择性向TI-Tregs,特别是它们的代谢途径,对于克服ICB耐药性至关重要.
- 代谢干预为ICI提供了潜在的辅助策略,可以增强抗瘤免疫力,而无需系统性免疫抑制.
- 未来的研究应该专注于确定TI-Tregs的特定代谢漏洞,以便开发新的治疗方法.
更多相关视频
06:38A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
14.4K
09:32Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
15.7K
相关概念视频
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
02:17The Tumor Microenvironment
8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
02:57Targeted Cancer Therapies
9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.1K