[从Croci Stigma获得的两个新的非循环烯酸]
Si-Bo Ji1, Ting-Ting Li1, Jun-Shi Tao1
1School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
概括
研究人员从Croci Stigma中发现了新的化合物,发现两种化合物通过抑制黑色素瘤细胞中的黑色素生成,具有显著的皮肤美白潜力.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- 克罗西·斯蒂格玛是一种传统的药用材料.
- 了解其化学成分对于探索其治疗潜力至关重要.
- 黑色素发生是皮肤色素和相关疾病的关键过程.
研究的目的:
- 隔离和阐明来自Croci Stigma的化合物的化学结构.
- 评估这些化合物作为黑色素生成抑制剂的潜力.
- 为了识别具有皮肤美白特性的新型化合物.
主要方法:
- 使用各种染色学技术 (凝,ODS,Sephadex LH-20,准备HPLC) 提取和分离.
- 使用光谱方法 (NMR,HR-MS,CD) 的结构阐明.
- 在实验室中评估B16F10黑色素瘤细胞中黑色素生成抑制.
主要成果:
- 隔离和鉴定了五种化合物:十字素A (1),十字素B (2),十字素C (3),十字素D (4) 和 (2E,4E) -2-甲基-6-oxo-hepta-2,4-dienoic酸 (5).
- 化合物1和2是新的;化合物3和4是新的自然产品.
- 化合物1和5在B16F10细胞中表现出显著的,剂量依赖的黑色素生成抑制.
结论:
- 克罗西·斯蒂格玛 (Croci Stigma) 含有具有潜在生物活性的新和新型天然化合物.
- 化合物1和5作为黑色素生成抑制剂具有前途.
- 这些发现表明,Croci Stigma衍生物在皮肤美白剂中的潜在应用.
相关概念视频
01:18Aromatic Hydrocarbon Cations: Structural Overview
4.1K
Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
Removing one hydrogen from the intervening CH2 group...
4.1K
01:26Thermal and Photochemical Electrocyclic Reactions: Overview
3.1K
Electrocyclic reactions are reversible reactions. They involve an intramolecular cyclization or ring-opening of a conjugated polyene. Shown below are two examples of electrocyclic reactions. In the first reaction, the formation of the cyclic product is favored. In contrast, in the second reaction, ring-opening is favored due to the high ring strain associated with cyclobutene formation.
3.1K
02:33Stereoisomerism of Cyclic Compounds
11.7K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
11.7K
01:29Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
6.3K
Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
6.3K
01:26Photochemical Electrocyclic Reactions: Stereochemistry
2.4K
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
Selection Rules: Photochemical Activation
2.4K
02:28Cycloalkanes
17.6K
Cycloalkanes are saturated cyclic hydrocarbons with carbon atoms arranged in the form of rings. They have two fewer hydrogen atoms than the corresponding acyclic alkane; therefore, their general formula is CnH2n. The structural formulas of cycloalkanes are simplified using the line-angle representation. The regular polygons are used to represent the cycloalkane rings, with each side representing a carbon-carbon bond.
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
17.6K