[基于UPLC-Q-TOF-MS的阿利斯马树的化学成分和原产地差异分析]
Tian-Tian Xu1, Shu-Yu Kang1, Song-Yuan Tang1
1State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine,Chinmedomics Research Center of National Administration of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine Harbin 150040,China.
概括
阿利斯马蒂斯树的起源显著影响其化学成分,具体化合物因地区而异. 这项研究为质量评估和选择高质量的Alismatis Rhizoma来源提供了基础.
科学领域:
- 植物化学 植物化学
- 分析化学 分析化学
- 化学测量 化学测量 化学测量
背景情况:
- 阿利斯马蒂斯树是一种传统的中医药,具有多种化学成分.
- 了解其化学特征的地理差异对于质量控制和治疗疗效至关重要.
研究的目的:
- 综合分析和比较来自不同生产领域的阿利斯马蒂斯树的化学成分.
- 为了识别差异化工标记,以进行原产地歧视.
主要方法:
- 超高性能液态染色学-四极飞行时间联质谱学 (UPLC-Q-TOF-MS) 用于化学分析.
- 多变量统计分析,包括主要组件分析 (PCA) 和正交部分最小平方差分分析 (OPLS-DA).
- 差异分析 (ANOVA) 用于选差异组件.
主要成果:
- 共有104种化学成分被确定,包括三类,六类,有机酸,氨基酸和黄类.
- 鉴定了18种不同的化学成分,其中2种是独一无二的,16种是常见的.
- 特定的化合物如1S,4S,10S-calamusin I和24-oxo-25-dehydro-alisol F分别被确定为福建和四川省的独特标记物.
结论:
- 阿利斯马蒂斯树的地理来源显著影响其化学成分.
- 特性化学成分可以有效地区分来源,有助于质量评估和优质来源的选择.
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