磁盘-状腺混合脂质纳米颗粒用于高效的药物封装和皮下输送
Zanelle van Niekerk1,2, Rima Nuwayhid3, Stefaniya Gaydarova4
1Department of Chemistry and Polymer Science, Stellenbosch University, Matieland, South Africa.
Small (Weinheim an der Bergstrasse, Germany)
|March 12, 2026
概括
从卡纳乌巴和红棕油中设计的新的脂质纳米颗粒 (LNP) 提供了强大的50nm以下载体,用于皮下药物输送. 这些生物相容的纳米颗粒显示出高度的药物封装和持续释放,从而提高了生物可用性.
科学领域:
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 有效的皮下和皮内药物输送需要具有增强生物可用性和生物相容性的系统.
- 脂质纳米粒子 (LNP) 是有前途的载体,但它们的配方需要优化稳定性和受控释放.
研究的目的:
- 设计和表征卡纳乌巴/红棕油脂质纳米粒子 (LNP) 用于皮下和皮内药物输送.
- 评估这些新型LNP的物理化学特性,药物封装效率,稳定性和生物相容性.
主要方法:
- 使用Cryo-TEM,SAXS和多检测非对称流场流量分成的系统物理化学分析.
- 生物评估包括人类纤维细胞,巨细胞和人体皮肤的长期活力测定.
- 用氨酸或二甲氨酸加载药物,以评估封装效率和稳定性.
主要成果:
- 工程LNPs表现出强大的50nm以下尺寸,具有圆形圆盘形形态 (30-40nm).
- 模型药物的封装效率达到了大约90%,而无需改变颗粒大小或结晶性.
- 配方表现出良好的生物相容性和持续释放,脂质透到接收介质的最小程度,表明局部存储效应.
结论:
- 卡纳乌巴/红棕油LNP的有目的矩阵工程产生了一个稳定的,生物相容的载体,用于皮下药物管理.
- 双表面活性剂冠状体改善了尺寸分散,这对于可预测的配方性能至关重要.
- 这些发现为优化皮下药物递送系统的配方-性质关系提供了宝贵的见解.
相关概念视频
Site-Targeted Drug Delivery Systems: Polymeric Carriers
79
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
79
Transdermal Drug Delivery Systems
87
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
87
Bioavailability Enhancement: Drug Permeability Enhancement
288
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
288
Modified-Release Drug Delivery Systems: Site-Targeted
70
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
70


