内皮激活和压力指数 (EASIX) 与美国老年人认知功能的关联:NHANES 2011-2014年的研究结果
Yiwen Xu1, Tianwen Huang1,2
1Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Journal of Alzheimer's disease : JAD
|March 12, 2026
概括
内皮激活和压力指数 (EASIX) 与老年人的认知能力下降有关. 较高的EASIX分数与认知测试的表现较差相关,这表明其作为认知衰老生物标志物的潜力.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
背景情况:
- 认知能力下降是老年人群的主要公共卫生问题.
- 内皮功能障碍是血管病理和认知障碍的公认因素.
- 内皮激活和压力指数 (EASIX) 是血管健康的潜在生物标志物,但其与认知的联系尚未被探索.
研究的目的:
- 调查EASIX与社区老年人的认知表现之间的关联.
- 为了确定EASIX是否可以作为认知衰老的生物标志物.
主要方法:
- 从2011-2014年NHANES中分析了2143名60岁以上的成年人的数据.
- 使用常规实验室测量计算EASIX: (肌素 × 乳酸脱酶) / 血小板计数.
- 使用CERAD-WL,AFT和DSST评估认知功能,使用回归模型进行统计分析.
主要成果:
- 每一个EASIX的单位增加都与DSST,AFT和CERAD-WL的分数下降有显著的关联.
- 较高的EASIX水平与AFT和DSST中认知功能障碍的几率增加相关.
- 在对共变量进行调整后,在敏感性分析中,这些关联仍然显著.
结论:
- 在老年人中,EASIX独立地与特定领域的认知衰退有关.
- EASIX显示出作为一种可访问的生物标志物,用于识别认知衰老的潜力.
- 进一步的研究可能会验证EASIX用于老年人群认知健康的临床评估.
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