基于Dibenzo-18-crown-6/poly-2-aminobenzenethiol的电位测量传感器用于化的确定:绿色评估
Ghada Ahmed El Sayed1, Sahar Mahmoud Mostafa1, Mohamed Rabia2
1Chemistry Department, Faculty of Science, Beni-Suef University Beni-Suef Egypt magdy_mmagdy@yahoo.com mohamed.mahmoud@science.bsu.edu.eg mohamedali_k@outlook.com.
RSC advances
|March 12, 2026
概括
一个新的碳糊度传感器用于Diltiazem化 (DTZ) 药物监测提供了高选择性和灵敏度. 这种绿色,具有成本效益的传感器在各种样本中提供快速和稳定的检测,有助于制药质量控制和临床诊断.
科学领域:
- 电分析化学 电分析化学
- 材料科学 材料科学 材料科学
- 药品分析 药品分析
背景情况:
- 丁胺 (DTZ) 需要精确监测治疗疗效和安全.
- 选择性和敏感传感器的开发对于有效的药物分析至关重要.
- 现有的分析方法可能缺乏常规监测所需的速度,成本效益或环保性.
研究的目的:
- 为DTZ开发和描述一个绿色,经济高效的碳糊电位传感器.
- 评估传感器的分析性能,包括选择性,灵敏性和稳定性.
- 为了证明传感器在现实世界样本中对药物监测的适用性.
主要方法:
- 用聚-2-氨基乙醇修改的碳糊电极的制造.
- 使用循环电压测量和电化学阻抗光谱学进行电化学表征.
- 在各种矩阵 (纯,制药,尿液,工业用水) 中电位测量DTZ的确定.
- 使用绿色分析指标 (AGREE,生态尺度,BAGI,RAPI) 评估传感器性能.
主要成果:
- 传感器在广泛的线性范围 (1.0 × 10-6 到 1.0 × 10-2 mol L-1) 上显示了 57.4 ± 0.81 mV 十年的纳尔斯蒂安斜率.
- 低检测极限为4.6×10−7molL−1,可实现快速响应 (<10秒) 和良好的稳定性 (pH2.0-8.0,6周寿命).
- 在药物配方,尿液和工业用水样本中成功确定DTZ,可接受的回收.
结论:
- 开发的碳糊电位传感器是绿色,经济高效,选择性和敏感的DTZ监控工具.
- 它在复杂矩阵中的强大性能和适用性表明其在临床诊断和制药质量控制中的潜在用途.
- 综合的绿色指标评估证实了传感器对传统方法的环境和实际优势.
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