在晚期甲状腺癌中,身体活动和全身治疗结果
Carla Colombo1,2, Daniele Ceruti3, Fabrizio Cervellini4
1Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Endocrine oncology (Bristol, England)
|March 12, 2026
概括
在癌症治疗期间保持体力活动可以改善治疗结果. 晚期甲状腺癌患者保持活跃,与不活跃患者相比,治疗中断较少,结果更好.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 临床试验 临床试验
背景情况:
- 身体活动对于管理癌症治疗副作用至关重要.
- 有限的研究存在于身体活动在晚期甲状腺癌治疗中的作用.
研究的目的:
- 评估身体活动水平和维持对接受激酶抑制剂治疗的晚期甲状腺癌患者的治疗安全性和疗效的影响.
主要方法:
- 包括28名接受酶抑制剂治疗的晚期甲状腺癌患者.
- 在三个时间点使用国际体育活动问卷测量身体活动.
- 使用RECIST v1.1标准来评估瘤反应.
主要成果:
- 与活跃患者相比,不活跃的患者经历了更多的治疗中断和疾病进展.
- 身体活动减少与治疗中断,不良事件,住院和疾病进展的增加相关.
- 在毒性和代谢等价物损失之间发现了显著的反相关性 (r = -0.15,P = 0.04).
结论:
- 保持体力活动与晚期甲状腺癌患者更好的治疗耐受性和治疗结果有关.
- 这些发现支持了对这一患者群体进行前性预康复研究的必要性.
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