美国成年人阿斯伯吉洛症诊断的流行病学使用国家EHR数据库,2013-2023年
Brittany L Morgan Bustamante1, Elijah G Martinez1, Aidan Lee2
1Division of Environmental Health Sciences, University of California, Berkeley, California, USA.
Open forum infectious diseases
|March 12, 2026
概括
在美国,阿斯伯吉洛症的诊断每年都在增加,男性,老年人和城市地区的诊断率更高. COVID-19不成比例地影响了西班牙裔/拉丁裔和少数群体,突出显示了不断变化的真菌感染趋势.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 公共卫生监督 公共卫生监督
背景情况:
- 阿斯伯吉洛症是一种严重的真菌感染,患者住院,发病率和死亡率都在增加.
- 美国的碎片化数据阻碍了对阿斯伯吉洛症的全面监测.
- 这项研究解决了了解阿斯伯吉洛症趋势和COVID-19影响的需要.
研究的目的:
- 评估美国阿斯伯吉洛症诊断的人口,地理和时间趋势.
- 为了评估COVID-19后出现的阿斯珀吉洛斯病模式的变化.
- 为菌病的临床识别和监测策略提供信息.
主要方法:
- 用美国142个医疗保健系统 (2013-2023) 的电子健康记录进行了回顾性队列研究.
- 分析了超过7600万成年患者的数据.
- 采用统计建模,包括准松和贝叶斯空间时间回归.
主要成果:
- 从2013年到2023年,阿斯伯吉洛症的患病率每年增加5%,在2022年达到顶峰.
- 在男性,老年人 (≥65) 和城市居民中观察到更高的患病率.
- 在COVID-19后,在西班牙裔/拉丁裔和少数群体中,患病率不成比例地增加.
结论:
- 全面的国家评估显示,阿斯珀吉洛斯病的流行率不断上升以及人口结构的变化.
- 这些发现支持在风险人群中更早地进行临床识别.
- 强调需要改善真菌病监测和诊断的准入.
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