在局部碳酸胺酶抑制剂后的抑郁和焦虑

Abdelrahman M Elhusseiny^1,2,3, Ahmad F Alzein⁴, Felipe A Medeiros³

¹Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Ophthalmology science

|March 12, 2026

概括

使用局部碳酸酶抑制剂 (CAI) 的青光眼患者面临更高的抑郁和焦虑风险. 在CAI治疗期间,监测这些神经精神影响至关重要.

科学领域:

眼科医生眼科眼科
精神病学是一个精神病学.
药理学药理学是指药理学的学科.

背景情况:

玻璃眼是全球不可逆转的失明的主要原因.
局部碳酸酶抑制剂 (CAI) 常用于对玻璃眼的治疗.
当前CAI的潜在神经精神病学副作用需要进一步调查.

研究的目的:

检查局部碳酸酶抑制剂 (CAI) 的使用与被诊断患有青光眼的患者中抑郁症和焦虑症的发病率之间的关联.

主要方法:

一项追溯的多中心队列研究,涉及40岁及以上的青光眼患者.
使用倾向分数匹配 (PSM) 来平衡局部CAI用户和对照组之间的共变量.
考克斯比例危险模型被用于确定抑郁症,抗抑郁药开始和焦虑障碍的调整危险比率 (aHR).

主要成果:

局部CAI使用与3个月 (1.42%对0.77%),6个月 (2.46%对1.41%) 和1年 (4.05%对2.47%) 的新发性抑郁症显著相关.
在所有时间点中,局部CAI组的抗抑郁药处方也更高.
在使用局部CAI的患者中,焦虑障碍发生的频率更高 (所有P<0.001).

结论:

在青光眼患者中,局部CAI治疗与患上抑郁症,开始抗抑郁药物治疗和在第一年内出现焦虑症的风险增加有关.
对接受局部CAI治疗的玻璃眼患者来说,对神经精神病学副作用的临床监测至关重要.

关键词:

焦虑焦虑是一种焦虑.布林佐胺是什么布林佐胺是什么抑郁症抑郁症抑郁症多尔佐胺胺是什么意思眼光障碍症是什么眼光障碍症是什么

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