在急性胰腺炎中,通过多原子分析发现的每日相位关系的丧失
Heather Waddell1,2, Xiaozhong Zheng1, Lucile Neyton1
1Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK.
Biochemistry and biophysics reports
|March 12, 2026
概括
循环节律的扰乱可能会加剧急性胰腺炎 (AP) 的严重程度. 这项研究在AP患者中发现了诸如CLOCK和BMAL1等昼夜基因和特定代谢物的改变表达,这表明了新的治疗点.
科学领域:
- * 时代生物学和胃肠道学
- * 疾病发病过程中的多组学.
背景情况:
- *急性胰腺炎 (AP) 是一种严重的炎症状况,缺乏向治疗.
- * 了解AP的发病因子对于开发新疗法至关重要.
- * 昼夜节律在AP中的作用在很大程度上仍未被探索.
研究的目的:
- * 调查昼夜节律失调在AP中的潜在参与.
- * 探索昼夜模式与AP疾病严重程度之间的关联.
- * 为了确定AP的潜在多原子生物标志物.
主要方法:
- *集成和分析多组学数据 (转录学,代谢学).
- *使用了AP患者的周围全血样本.
- *在24小时内检查了节律性基因表达和代谢物概况.
主要成果:
- *确定了昼夜节律失调与AP严重程度之间的潜在联系.
- *观察到关键的昼夜基因 (例如,CLOCK,BMAL1) 的节律表达发生变化.
- * 在AP患者中发现特定代谢物子集的变化.
结论:
- * 循环节律失调可能在AP病变发生中起作用.
- * CLOCK,BMAL1基因和特定的代谢产物在AP中表现出改变的节律表达.
- *这些发现支持进一步研究针对AP疗法的昼夜节律.
相关概念视频
Chronic Pancreatitis I: Introduction
832
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
832
Acute Pancreatitis I: Introduction
1.4K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.4K
Acute Pancreatitis II: Clinical Manifestations and Management
1000
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1000
Chronic Pancreatitis II: Collaborative Care
452
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
452


