饮食炎症指数对良性前列腺增生症的影响:来自患者数据和动物模型的见解
Jingwei Ke1, Sheng Wang2, Xinyang Liao2
1Department of Urology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Frontiers in nutrition
|March 12, 2026
概括
促炎症饮食增加了良性前列腺增生 (BPH) 的风险,而抗炎症饮食可能会提供保护. 这项研究提供了证据,表明饮食炎症在BPH发展中起着因果作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 营养科学 营养科学
- 炎症研究 炎症研究
背景情况:
- 良性前列腺增生 (BPH) 是老年男性普遍存在的疾病,导致下泌尿道症状 (LUTS).
- 人们怀疑饮食和BPH之间的联系,但尚未完全理解.
- 调查饮食炎症指数 (DII) 和BPH因果关系至关重要.
研究的目的:
- 检查DII和BPH之间的因果关系.
- 评估特定饮食模式对BPH风险的影响.
- 探索饮食调节作为BPH管理的策略.
主要方法:
- 使用NHANES数据进行横截面队列分析,以评估DII和BPH相关性.
- 两个样本的孟德尔随机化 (TS-MR) 用于确定BPH饮食模式的遗传因果关系.
- 用促炎和抗炎饮食进行动物实验,以验证发现.
主要成果:
- 较高的DII得分与增加的BPH风险有显著的相关性.
- 基因预测的抗炎饮食显示与BPH风险有相反的关联.
- 在老鼠中,支持炎症的饮食导致前列腺扩大和炎症标志物增加;抗炎症饮食减轻了这些影响.
结论:
- 饮食中的炎症负荷因果关系有助于BPH的发展.
- 促炎饮食通过持续的炎症促进BPH; 抗炎饮食可能具有保护作用.
- 饮食改变为BPH提供了潜在的预防和治疗方法.
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