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在CKM综合征中,TyG和RC结合心血管疾病风险:一项国家队列研究
Hongtao Lan1, Xu Jia2,3, Zheng Zhao1
1Department of Cardiology, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao 266100, China.
iScience
|March 12, 2026
概括
甘油三糖 (TyG) 指数和残留胆固醇 (RC) 共同预测代谢综合征中的心血管疾病 (CVD) 风险. 一个新的TyG-RC指数比单个标志物更有效地改善心血管疾病风险评估.
科学领域:
- 心血管疾病研究研究
- 代谢综合征研究 代谢综合征研究
- 生物标志物发现发现
背景情况:
- 三甘油-葡萄糖指数 (TyG) 和残留胆固醇 (RC) 是心血管疾病 (CVD) 风险因素在心血管--代谢 (CKM) 综合征.
- 然而,TyG和RC对心血管疾病风险的联合预测能力需要进一步探索.
研究的目的:
- 调查甘油三指数 (TyG) 和残留胆固醇 (RC) 对心血管疾病 (CVD) 风险的联合预测能力.
- 开发和验证一种新的TyG-RC指数,用于在CKM综合征中增强心血管疾病风险分层.
主要方法:
- 利用了来自中国健康与退休长度研究 (2020) 的数据,平均随访时间为9.0年.
- 计算了参与者的甘油三糖指数 (TyG) 和残留胆固醇 (RC).
- 通过乘以TyG和RC值,开发了TyG-RC指数.
- 执行了Cox比例危险回归和时间独立的ROC分析.
主要成果:
- 具有高TyG和高RC的个体表现出显著升高的心血管疾病风险 (HR = 1.35).
- 新型TyG-RC指数的每一次1-SD增加都与心血管疾病风险的增加有关,显示出一个反向的J形关系.
- 与TyG-BMI,TyG-WC,TyG-WHtR,eGDR和METSIR等其他指数相比,TyG-RC指数显示了对心血管疾病的优异预测性能.
结论:
- 使用TyG-RC指数的联合评估为心血管疾病风险评估提供了比单独使用TyG或RC更有效的工具.
- TyG-RC指数为改善代谢功能障碍患者心血管疾病风险分层提供了一个有希望的方法.
关键词:
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