骨质疏松症和肠道微生物群:目前的理解
Yikai Liu1, Shuai Lu1,2, Ruifeng Bai3
1Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China.
Frontiers in immunology
|March 12, 2026
概括
肠道微生物群 (GM) 显著影响骨质疏松症 (OP) 的发展. 用益生菌调节肠道细菌可能为管理骨密度下降和预防骨折提供一种新的治疗策略.
科学领域:
- 微生物学 微生物学
- 骨生物学 骨生物学 骨生物学
- 免疫学 免疫学 免疫学
背景情况:
- 骨质疏松症 (OP) 是老年人常见的疾病,其特征是骨矿物质密度 (BMD) 降低和骨折风险增加.
- 骨再吸收和骨形成之间的不平衡是OP病变的核心.
- 新兴研究强调了肠道微生物群 (GM) 在OP发展中的关键作用.
研究的目的:
- 审查当前对肠道微生物群如何影响骨质疏松病变的理解.
- 探索转基因影响骨代谢的机制,包括代谢物产生,肠道屏障功能和免疫调节.
- 讨论针对OP干预的转基因向的治疗潜力.
主要方法:
- 关于肠道微生物群和骨质疏松症的最新研究的文献综述.
- 对将转基因与骨健康,免疫力和肠道屏障完整性联系起来的机制的分析.
- 综合了关于抗生素和益生菌对骨代谢的影响的研究结果.
主要成果:
- 肠道功能失调可以加速OP的进展,而有益的细菌 (益生菌) 可以支持骨健康.
- 转基因通过代谢物产生,调节肠道透性和调节免疫和骨免疫反应来影响OP.
- 特定的细菌物种及其代谢物越来越被认为是骨重塑的关键参与者.
结论:
- 肠道微生物群在骨质疏松症的发病过程中发挥着重要作用.
- 准肠道微生物群为新的OP预防和治疗策略提供了一个有希望的途径.
- 对肠-骨轴的进一步研究对于开发有效的基于微生物组的骨质疏松症疗法至关重要.
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