COVID-19与"三种炎症和一种聋"之间的关系:系统性审查和元分析
Lisha Liu1,2, Hong Zhao1,2, Jing Qiao1,2
1Department of Otolaryngology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Frontiers in immunology
|March 12, 2026
概括
这次元分析发现COVID-19和"三种炎症和一种聋"之间没有一致的联系. 然而,当结果被医生诊断时,观察到一个显著的关联,强调了诊断标准在研究中的重要性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- COVID-19与过敏性鼻炎,喉炎,中耳炎,耳和聋等疾病之间的关系尚不清楚.
- 这项研究调查了2019年冠状病毒病 (COVID-19) 和被称为"三种炎症和一种聋"的疾病集群之间的潜在关联.
研究的目的:
- 进行一项元分析,研究COVID-19感染与"三种炎症和一种聋"之间的关联.
- 探索研究结果中的异质性,并确定影响观察到的关联的因素,例如诊断标准.
主要方法:
- 在Embase,Cochrane图书馆和PubMed进行了系统的文献搜索,直到2024年7月.
- 在严格选,数据提取,质量评估和使用随机效应模型进行元分析后,包括了五项队列研究.
主要成果:
- 整体综合分析显示,COVID-19与"三种炎症和一种聋" (OR = 1.03,P = 0.74) 之间没有统计学上显著的关联,具有实质性的异质性 (I2 = 89%).
- 亚组分析表明,当结果被医生诊断时 (OR = 1.30,P = 0.006,I2 = 0%),但不是对自我报告的症状 (OR = 0.89,P = 0.38,I2 = 96%) 存在显著的关联.
- 听力损失没有发现显著的关联,而过敏性鼻炎和耳则显示出非显著的积极趋势.
结论:
- 由于研究方法的显著异质性,COVID-19和"三种炎症和一种聋"之间没有一致的关联.
- 建议COVID-19和医生诊断的"三种炎症和一种聋"之间存在潜在的联系,强调标准化临床评估在未来研究中的关键作用.
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