跨种族族群血压血动力学和白质超强度体积的性别差异-HABS-HDHD
Cellas A Hayes1, Anthony Q Briggs2, Joshua L Gills2,3,4
1Stanford University School of Medicine Department of Epidemiology and Population Health Palo Alto California USA.
Alzheimer's & dementia (New York, N. Y.)
|March 12, 2026
概括
血压 血压 血压 血压
科学领域:
- 神经学 神经学
- 血管生物学 血管生物学
- 公共卫生 公共卫生
背景情况:
- 血压成分与白质强度过高 (WMH) 负担之间的关系在不同人群中尚未完全理解.
- 了解这些关联对于识别性别和种族/种族特异性脑血管风险至关重要.
研究的目的:
- 为了研究系统血压 (SBP),透气血压 (DBP),脉冲压 (PP) 和平均动脉压 (MAP) 与WMH体积的关系.
- 检查这些关联是否在非西班牙裔白人 (NHW),非西班牙裔黑人 (NHB) 和西班牙裔成年人中因性别而异.
主要方法:
- 利用了来自健康和衰老大脑研究-健康差异 (HABS-HD) 的数据,包括NHW,NHB和西班牙裔成年人.
- 采用线性回归模型来评估BP组件和WMH体积之间的关联,按种族/种族和性别分层.
- 根据主要的人口和健康因素进行调整,包括年龄,教育程度,糖尿病和吸烟情况.
主要成果:
- 在NHW个体中,更高的SBP和PP与女性与男性更大的WMH有关.
- 在NHB参与者中没有观察到BP-WMH关联的显著性别差异.
- 在DBP和MAP调整的模型中,西班牙裔女性的WMH更大,但在男性中,BP-WMH总体关联更强.
结论:
- 血压与WMH的关联在不同种族和种族群体中因性别而异.
- 这些发现揭示了脑血管脆弱性的复杂相互作用,表明小血管疾病的性别特异性途径.
- 针对大脑健康的血压干预措施可能需要根据性别和种族/民族背景量身定制.
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