皮质醇/DHEA比率升高调解了症状严重程度和工作记忆障碍之间的关联,在未经药物治疗的第一期强迫症患者中
Fangqing Song1,2, Yuhan Li1,2, Shaoxia Wang1,2
1School of First Clinical, Ningxia Medical University, Yinchuan, Ningxia, China.
在早期的强迫症 (OCD) 中,皮质醇/脱氨 (DHEA) 比率升高,预示着抑制控制和工作记忆的认知缺陷. 这种神经内分泌失衡可能会调解强迫症症状严重程度和认知障碍之间的联系.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 认知神经科学 认知神经科学
背景情况:
- 脑下垂体上腺 (HPA) 轴的失调与强迫症 (OCD) 病理生理学和认知缺陷有关.
- 皮质醇/脱氨 (DHEA) 的比率,反映了代谢/代谢平衡,在早期的强迫症中不太了解.
研究的目的:
- 为了研究皮质醇/DHEA比率与未服用药物,首发强迫症患者的执行功能之间的关联.
- 探索皮质醇/DHEA比率作为早期强迫症认知缺陷的潜在生物标志物.
主要方法:
- 招募了75名未经药物治疗的第一期强迫症患者和50名健康对照 (HCs).
- 使用ELISA测量了血皮质醇和DHEA水平.
- 执行功能,包括响应抑制,工作记忆和认知灵活性,使用标准化任务进行评估.
主要成果:
- 强迫症患者表现出反应抑制和工作记忆的缺陷,皮质醇升高,DHEA降低,与HC相比,皮质醇/DHEA比率更高.
- 皮质醇/DHEA比率与强迫症症状严重程度和较差的抑制控制相关.
- 皮质醇/DHEA比率独立预测了反应抑制缺陷,并调解了症状严重程度和工作记忆精度之间的关系.
结论:
- 皮质醇/DHEA比率升高是药物原始性强迫症的特征,并预测抑制功能障碍.
- 皮质醇/DHEA比率似乎调解了强迫症症状对工作记忆的影响.
- 皮质醇/DHEA比率可以作为一种依赖状态的生物标志物,表明神经内分泌平衡的恢复是强迫症相关认知缺陷的治疗目标.
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