肠道抗体在家禽生产中:微生物生态学,抗生素使用和可持续控制方法
Zonghui Jian1, Yuwei Qian2, Shichun He1
1Yunnan Vocational and Technical College of Agriculture, Kunming, China.
Frontiers in microbiology
|March 12, 2026
概括
在家禽养殖中使用抗生素会在肠道微生物群中产生抗生素耐药性基因 (ARG) 的储备. 了解耐药性-微生物组-代谢组轴是制定减轻抗菌素耐药性的策略的关键.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 抗生素在家禽生产中至关重要,但它们的使用导致了肠道中显著的抗生素耐药基因 (ARG).
- 禽类肠道微生物组是ARG的储存库,受细菌宿主,移动遗传元素和生产系统的影响.
研究的目的:
- 审查家禽抗体的结构和功能方面.
- 评估抗生素使用和共同选择性压力如何影响微生物群落和ARG持久性.
- 探索传播途径和干预措施以缓解抗微生物耐药性.
主要方法:
- 文献综述综合了目前对家禽抗体的理解.
- 对细菌宿主,移动遗传元素和代谢条件的分析.
- 评估抗生素使用模式和共同选择性压力.
主要成果:
- 禽类抗体组合反映了细菌分类,移动遗传元素和环境因素.
- 抗生素使用模式显著改变微生物群落,促进ARG持久性.
- 传播途径将家禽生产和便管理的各个阶段联系起来.
结论:
- 抵抗体-微生物体-代谢体轴连接微生物群落,耐药性基因和代谢信号.
- 这一框架可以指导有针对性的战略,以减少家禽的抗菌素耐药性.
- 微生物和营养干预措施对影响肠道健康和耐药性的表现有希望.
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