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Updated: Mar 13, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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通过增加BCL2L1表达,NSUN2-FOSB互惠促进了m5C依赖的白血病发生,从而增加了BCL2L1表达

Bin Zhou1, Yigang Yuan1, Yue Cai2

  • 1Medical Research Center, The First Affiliated Hospital of Wenzhou Medical University, 1 Xuefubei Street, Ouhai District, Wenzhou, Zhejiang Province.

Haematologica
|March 12, 2026
PubMed
概括

RNA甲基转移酶NSUN2在急性髓性白血病 (AML) 中被上调,并通过稳定FOSB mRNA来驱动白血病发生. 准NSUN2-FOSB-BCL2L1通路为AML提供了一个潜在的治疗策略.

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