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狗尿细胞DNA突变与市政饮用水中的三甲总度无关
Janice O'Brien1, Samantha L Braman2, Jennifer Willcox3
1Department of Population Health Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA.
Veterinary and comparative oncology
|March 12, 2026
概括
饮用水中的三甲总量 (TTHMs) 是致变基因的,并与泌尿腺癌 (UC) 有关. 这项研究没有发现TTHM和狗尿路BRAF突变之间的直接联系,这表明其他因素会影响狗的UC风险.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 环境健康 环境健康
- 狗类瘤学 狗类瘤学
背景情况:
- 城市饮用水中的诸如总三甲 (TTHMs) 等致变性污染物与人类和狗的泌尿腺癌 (UC) 有关.
- 遗传突变,包括BRAF基因突变和空白尿细胞中的副本数异常,与狗的UC有关.
研究的目的:
- 为了研究市政饮用水TTHM度与尿路BRAF突变或基因组副本数异常在狗中的发生率之间的关联.
- 为了比较来自高TTHM水平 (拉斯维加斯) 和低TTHM水平 (雷诺) 的地区和整个美国的狗的突变率.
主要方法:
- 生态研究比较犬类尿道BRAF/BRAF-PLUS测试结果和市政饮用水TTHM度,按美国邮政编码划分.
- 分析包括对拉斯维加斯和雷诺之间的突变发病率进行比较,以及对人口和地理因素进行横截面分析.
主要成果:
- 拉斯维加斯的狗与雷诺的狗相比,尿突变的相对风险更高,但这不能归因于更高的TTHM水平.
- 在美国各地,尿路细胞突变与市政用水TTHMs无关.
- 与突变相关的因素包括年龄较大,绝育状态,更高的区域测试提交率,以及UC的特定高风险品种.
结论:
- 该研究没有发现TTHM暴露与狗尿路BRAF突变之间的直接联系.
- 拉斯维加斯更高的突变检测率可能是由于测试提交率增加而不是TTHM水平.
- 其他环境暴露或诸如年龄和品种之类的因素与TTHMs相比,与犬类泌尿管突变的相关性更强.
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