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Updated: Mar 13, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

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尼帕尔1驱动一种代谢-表观遗传反循环,以促进食道癌中的乳酸介导免疫逃避

Ri-Xin Chen1,2,3, Xiao-Dan Ma2, Shui-Dan Xu2,4

  • 1Department of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 12, 2026
PubMed
概括

一个涉及NIPAL1,HCK和乳酸的新型代谢-表观遗传电路增强了食道状细胞癌 (ESCC) 的生长和免疫逃避. 针对这一循环可能会改善ESCC患者的免疫疗法疗效.

关键词:
尼帕尔 (NIPAL) 是一个食管状细胞癌的癌症基因素乳酸化 基因素乳酸化免疫逃避 免疫逃避乳酸乳酸是一种乳酸.

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