交替高脂肪和多糖饮食调节肠道菌体-细菌相互作用
Fengxiang Zhao1, Ruiqi Zhang1, Rujun Wei1
1College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 12, 2026
概括
饮食极大地影响肠道病毒 (菌素) 和它们与细菌的相互作用. 高脂肪饮食会改变菌体的丰富性和活性,而富科伊丹可以恢复平衡并促进基因转移.
科学领域:
- 微生物学 微生物学
- 肠道微生物组研究研究
- 病毒组动力学 病毒组动力学
背景情况:
- 菌体 (菌体) 是人类肠道病毒组的关键参与者,调节细菌种群.
- 以前关于饮食对肠道菌体的影响的研究规模有限.
- 了解饮食-病毒组相互作用对于肠道健康至关重要.
研究的目的:
- 系统地研究饮食对肠道病毒和菌菌相互作用的影响.
- 描述不同的饮食,包括高脂肪和富含多糖的饮食,如何塑造病毒组.
- 探索由菌体介导的基因转移和受饮食影响的代谢功能.
主要方法:
- 对6932个与饮食相关的人类元基因组的元分析.
- 时间解决的小鼠模型养高脂肪饮食和多糖.
- 对菌-细菌相互作用,丰富性,生活方式和辅助代谢基因的分析.
主要成果:
- 饮食是肠道病毒组合和菌-细菌交叉声的主要驱动因素.
- 高脂肪饮食显著改变菌体的丰富性,并促进性生活方式,丰富氨基酸代谢基因.
- 富科伊丹逆转了高脂肪饮食诱导的失生症,并增加了菌媒介水平基因转移的8.5倍.
结论:
- 饮食干预,如富科伊丹,可以调节肠道病毒组合和功能.
- 特定的菌体 (例如,crAssphages,Parabacteroides菌体) 在基因转移和新陈代谢中发挥作用.
- 研究结果为针对性微生物群调节的营养策略提供了见解.
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