用加素载荷的聚合物微粒剂添加蚀冲洗粘合剂系统的物理化学特征
Jiovanne Rabelo Neri1, Nadine Luisa Guimarães Albuquerque1, Marcelo Victor Sidou Lemos2,3
1Graduate School of Dentistry, University Center Christus, Fortaleza, Ceará, Brazil.
European journal of oral sciences
|March 12, 2026
概括
这项研究成功地将带有epigallocatechin-3-gallate (EGCG) 的微粒纳入牙粘合剂中,实现了受控的EGCG释放,而不会随着时间的推移对材料特性或粘合强度产生负面影响.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 聚合物化学 聚合物化学
背景情况:
- 乙甲基-3-酸盐 (EGCG) 对牙科应用具有有益的特性.
- 由于稳定性和释放动力学,直接将EGCG纳入粘合剂可能具有挑战性.
- 聚乳酸-同糖化物 (PLGA) 微粒为控制药物输送提供了一个潜在的解决方案.
研究的目的:
- 评估将带有EGCG的PLGA微粒纳入两步蚀刻和冲洗牙粘合剂中的方法.
- 评估这些微粒对粘合剂的物理化学特性和EGCG释放概况的影响.
- 用修改的粘合剂来确定粘合强度的长期稳定性.
主要方法:
- EGCG被直接纳入或封装在PLGA 50:50或75:25微粒中.
- 测试了物理化学特性 (直流,屈曲强度,弹性模量,水吸附,可溶性).
- 实验室EGCG释放和微拉伸键强度 (TBS) 在24小时,6个月和12个月后被评估.
主要成果:
- 1%的PLGA 50:50/EGCG显示了最高的累积EGCG释放量 (77.30μg).
- 没有观察到对转化程度,弹性模量,水吸附或溶解度的显著不良影响.
- 与对照组不同的是,所有实验组的债券强度在12个月内都保持稳定.
结论:
- 将1%的EGCG载荷的PLGA 50:50微粒纳入单键2是控制EGCG释放的可行策略.
- 这种方法保持了牙粘合剂的关键物理化学和机械性能.
- 修改后的粘合剂显示出有希望的长期粘合耐用性,这表明了潜在的临床益处.
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