在唾液和口腔抽样上对肺结核的分子检测的诊断准确性
Deninson Alejandro Vargas1,2, Jose Fernando Fuertes-Bucheli1,3, Andrea Sanchez-Hidalgo1
1Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.
概括
使用唾液和口腔抹布进行快速分子检测,显示出对结核病 (TB) 的诊断具有很高的准确性. 唾液检测显示出优异的灵敏度,达到非吐结核病诊断的全球目标.
科学领域:
- 传染性疾病 传染性疾病
- 分子诊断学 分子诊断学
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 诊断需要快速,准确的,非唾液测试,以提高检测率.
- 评估其他样本类型,如唾液和口腔抹布,对于可访问的结核病诊断至关重要.
研究的目的:
- 评估分子测试的诊断性能,以唾液和口腔抹布为肺结核.
- 为了比较唾液和抽样测试与唾液培养的灵敏度和特异性.
主要方法:
- 进行了一项嵌套病例控制研究,共190名参与者 (95名结核病确诊,95名对照).
- 为了进行Xpert MTB/RIF Ultra测试,采集了配对的唾液,唾液和口腔抹布样本.
- 诊断准确度指标 (灵敏度,特异性) 被计算和比较.
主要成果:
- 唾液检测显示肺结核的灵敏度为90.5%,特异性为95.8%.
- 口服抽样测试显示71.6%的灵敏度和99%的特异性.
- 唾液灵敏度明显高于抽样灵敏度 (18.9%的差异,P < .001).
结论:
- 唾液和口腔抽样都具有高度敏感性和特异性,用于诊断培养确认的肺结核.
- 唾液检测超过了世卫组织针对低复杂性非吐结核病诊断测试的≥80%的目标灵敏度.
相关概念视频
01:26Pulmonary Tuberculosis IV
600
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
600
01:20Sputum Studies II: Culture and Sensitivity
1.6K
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
1.6K
01:31Pulmonary Tuberculosis III
1.3K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.3K