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腺病毒载体和子单元蛋白的组合会引起针对SARS-CoV-2 Omicron变异的强有力的免疫反应

Chunjun Ye¹, Xiya Huang¹, Weiqi Hong¹

¹Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan, 610041, People's Republic of China.

Molecular biomedicine

|March 12, 2026

概括

一种结合腺病毒载体和子单元蛋白质的新型两成分疫苗显示出对抗SARS-CoV-2变种的前景. 这种新的COVID-19疫苗策略引起了持久的免疫力,可以增强对新兴菌株 (如JN.1.1) 的保护.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
疫苗学疫苗学疫苗学

背景情况:

随着SARS-CoV-2变种的不断出现,疫苗的有效性正在下降.
新型疫苗平台对于对不断演变的病毒进行持续保护至关重要.

研究的目的:

开发和评估一种用于增强SARS-CoV-2免疫力的两组疫苗平台.
评估疫苗的潜力,作为一个独立的和异质的增强剂策略.

主要方法:

设计了一种具有腺病毒载体 (Ad5_XBB.1.5) 和自我组装蛋白质 (RBD_XBB.1.5-HR或RBD_JN.1-HR) 的疫苗.
向小鼠肌肉内注射疫苗,以评估幽默和细胞免疫反应.
在mRNA原始化 (mRNA_BA.4,mRNA_XBB.1.5) 之后,作为异质增强剂测试了疫苗.

主要成果:

这种两组分的疫苗在小鼠中诱导了持续超过六个月的强大而持久的IgG反应.
它产生了显著的记忆B细胞和长寿等离子体细胞种群.
该疫苗有效地促进了对JN.1等变体的中和,在异构的原始增强环境中.

结论:

这种两组分的疫苗系统提供了强大的独立免疫力,并作为一种有效的异质增强剂.
它的模块化设计允许对未来的SARS-CoV-2变种和其他呼吸道病毒进行快速适应.
这个平台为下一代针对病毒多样化的COVID-19疫苗提供了可通用的框架.

关键词:

亚地诺病毒载体亚地诺病毒载体奥米克朗变种的变种这就是SARS-CoV-2病毒.三分化RBD蛋白质的三分化这是一种两组分的疫苗.

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