在西班牙参与abemaciclib患者支持计划的晚期乳腺癌患者的临床经验和满意度:一项前性观察性研究
Isabel Blancas1,2,3, Miriam González de la Peña4, María Fernández Abad5
1Hospital Universitario Clínico San Cecilio, Granada, Spain. isabelblancas@hotmail.com.
概括
一个患者支持计划 (PSP) 在转移性乳腺癌患者中有效管理了abemaciclib相关的腹. 该计划确保了良好的治疗坚持和高的患者满意度,支持其在临床实践中的使用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 患者支持计划 患者支持计划
背景情况:
- 阿贝马西克利布是一种CDK4/6抑制剂,用于激素受体阳性,HER2阴性转移性乳腺癌 (HR+/HER2-MBC).
- 腹是abemaciclib常见的副作用,可能会影响治疗坚持和患者报告的结果.
- 患者支持计划 (PSP) 可以在管理与治疗相关的毒性和改善患者坚持治疗方面发挥关键作用.
研究的目的:
- 评估患者支持计划 (PSP) 对管理abemaciclib相关腹的影响.
- 评估PSP对HR+/HER2-MBC患者治疗坚持和患者报告结果的影响.
- 为了确定PSP在常规临床实践中对abemaciclib治疗的有效性.
主要方法:
- 在西班牙进行了一项多中心的前性观察性研究,持续了6个月.
- 评估了接受abemaciclib并被纳入PSP的局部晚期或MBC患者.
- 主要终点:由于腹而减少或停止服用abemaciclib的患者比例. 二级终点:腹管理,坚持,HRQoL和PSP满意度.
主要成果:
- 39名患者中有89.7%发生了腹,大多为1-2级;没有报告≥4级事件.
- 23.1%的患者需要修改治疗,但由于腹而没有永久停药.
- 在24周观察到患者对PSP的高满意度 (>70%) 和良好的治疗坚持 (80%).
结论:
- 与abemaciclib相关的腹是可以控制的,没有报告永久性停止治疗.
- PSP有助于高患者满意度,良好的坚持和良好的生活质量.
- 这些发现支持将PSP纳入临床实践,用于HR+/HER2-MBC的abemaciclib治疗.
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