对前列腺癌全身治疗的陈述偏好:对离散选择实验文献的有针对性的审查
Neeraj Agarwal1, Brett Hauber2, Agnes Hong3
1Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
The patient
|March 12, 2026
概括
患者和医疗保健专业人员优先考虑前列腺癌 (PC) 治疗疗效. 然而,对特定副作用的偏好因PC阶段和受访者类型而异,影响治疗决策.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 患者报告的结果
背景情况:
- 前列腺癌 (PC) 的全身疗法已经进步,改善了生存率.
- 了解患者和医疗保健专业人员 (HCP) 对治疗权衡的偏好对于决策至关重要.
- 离散选择实验 (DCE) 研究评估了PC治疗中生存与副作用的偏好.
研究的目的:
- 审查和综合DCE研究中关于患者和医疗人员对系统PC疗法的偏好的研究结果.
- 根据PC阶段和受访者类型,确定对疗效,安全性和耐受性属性的偏好如何不同.
主要方法:
- 针对PC DCE研究进行了PubMed的有针对性的文献综述,该研究的期限为2025年4月.
- 研究被分类为"早期阶段" (雌激素剥夺疗法) 或"晚期阶段" (转移性/抵抗割的PC疗法).
- 属性重要性排名被描述性地总结,并按受访者类型和PC阶段进行分层.
主要成果:
- 包括17项研究,评估早期阶段 (4项研究) 和晚期 (13项研究) 的PC治疗.
- 患者和医疗人员都将疗效结果 (例如整体存活率) 列为最重要的.
- 避免特定副作用的偏好各不相同;晚期研究优先考虑长期安全性,而早期研究重点关注短期耐受性.
结论:
- 在前列腺癌治疗的各个阶段,对患者和医疗人员来说,疗效结果至关重要.
- 在患者和医疗人员之间以及不同PC阶段之间,安全性和耐受性属性的重要性存在差异.
- 这些细微的偏好应考虑在前列腺癌护理中支持最佳治疗决策.
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