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    科学领域:

    • 医疗成像医学成像
    • 生物光子学 生物光子学
    • 手术技术 手术技术

    背景情况:

    • 近红外光 (NIRF) 成像系统通常需要多个操作员,并且缺乏标准化的获取约束,限制可重现性.
    • 由于几何结构和数据流不一致,现有的系统阻碍了无手操作和定量分析.

    研究的目的:

    • 开发一个单操作员,可穿戴的癌症视觉眼镜 (CVG) 平台,用于无手指导NIRF指导.
    • 通过标准化采集几何形状和保持忠实的参考流来实现可重复的定量NIRF成像.

    主要方法:

    • 一个装在头部的望远镜系统,集成同步的可见/NIR摄像头,光学透视显示器和对齐激光器.
    • 无手操作通过蓝牙脚踏板和GUI进行快照捕捉.
    • 使用幻象和体内/体外瘤模型进行性能验证.

    主要成果:

    • 在50厘米的标准距离上,CVG系统实现了281微米的空间分辨率.
    • 幻影研究显示了高的信号与背景比率和线性行为.
    • 在小鼠和人类标本中观察到与瘤相关的一致NIRF局部化,通过实时值进行了增强的划分.

    结论:

    • CVG平台提供了一个可穿戴的,单操作员NIRF成像解决方案,具有标准化的采集,集成的安全性和无手工作流.
    • 该系统支持可重现的光成像,并促进生成可分析的翻译数据集.