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Updated: Mar 14, 2026

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
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电荷逆转蛋白解聚合物使组织特异性STING降解在类风湿性关节炎

Xu He1,2, Lidong Gong3, Juqi Zhang1,2,4

  • 1Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, People's Republic of China.

Proceedings of the National Academy of Sciences of the United States of America
|March 12, 2026
PubMed
概括

研究人员开发了称为CreTACs的智能STING降解剂,用于类风湿性关节炎 (RA). 这种pH触发系统针对STING蛋白变体,降低毒性,改善药物输送到炎症关节.

关键词:
在STING调制器.电荷逆转聚合物的聚合物.微观环境响应的交付方式适应pH值的材料有针对性的蛋白质降解降解.

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