在接受食道切除术的食道癌患者中,为吞功能进行术前呼吸肌肉训练:一项随机对照的II期试验协议
Hiroki Mizusawa1, Masaya Noguchi1, Tomomi Tamura1
1Department of Rehabilitation Medicine, Kindai University Hospital, Osaka, Japan.
PloS one
|March 12, 2026
概括
手术前的呼吸肌肉训练 (EMT) 可能改善食道癌的食道切除术后的吞. 这项试验调查了EMT是否可以减少手术后食症,这可能为手术患者提供一种新的预康复策略.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
背景情况:
- 消化管癌的消化管切除术是侵入性的,往往导致手术后的消化不良.
- 最少侵入性技术可以减少肺部问题,但不能减少吞困难.
- 术前呼吸道肌肉训练 (EMT) 显示出改善肌肉功能的潜力,但其在食道癌患者中的作用尚未得到充分研究.
研究的目的:
- 为了评估术前呼吸肌肉训练 (EMT) 对术后吞功能的有效性,在为胸腔食道状细胞癌接受食道切除手术的患者中.
- 评估EMT是否可以减少手术后食障碍的发生率和严重程度.
- 探索EMT作为一种潜在的预康复策略,以增强外科康复.
主要方法:
- 第二阶段,随机,受控,双盲试验,涉及40名接受食道切除术的患者.
- 患者被分为1:1的EMT组 (使用EX-1 Medic®设备在50-70%的最大呼气压下) 或假EMT组 (最小阻力).
- 主要结局:在术后视频光镜吞研究 (POD 10) 中,透吸收量级得分. 二次结果包括舌头压力,吞测试,呼吸肌肉强度,肌肉质量指数和运动耐受性.
主要成果:
- 本节不适用,因为该研究正在进行中,结果尚未提供.
结论:
- 这项试验旨在确定手术前的EMT是否改善吞功能,并减少因食道癌而进行食道切除术后的消化不良.
- 这些发现可以将EMT确立为一种新的预康复策略,提高患者的治疗结果和在外科瘤治疗中恢复.
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