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上转化介导的光疗用于牛皮治疗

Xiaoyu Ji¹, Zhenjia Lin², Ni Ding²

¹PCFM Lab, Guangdong Engineering Technology Research Centre for Functional Biomaterials, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510006, China.

ACS applied bio materials

|March 12, 2026

概括

上转化纳米粒子 (UCNPs) 为牛皮提供了一种新的光疗法. 这种治疗将促炎性巨细胞转换为抗炎状态,改善皮肤炎而无光毒性.

科学领域:

免疫皮肤学免疫皮肤学
纳米医学是一种纳米医学.
照相医疗 (photomedicine) 是一种医学技术.

背景情况:

牛皮是一种慢性炎症性皮肤病,在全球影响2-3%,目前的治疗方法会引起副作用.
牛皮皮炎的现有疗法没有治愈,可能导致感染或光毒性.

研究的目的:

在牛皮治疗中研究升级转化纳米粒子 (UCNPs) 用于增强体内光疗.
评估UCNP介导的光疗对牛皮的巨细胞的免疫调节作用.

主要方法:

用于光疗的808nm近红外 (NIR) 光激活的上转化纳米粒子 (UCNPs).
分析了对UCNP光疗的反应中的巨分化 (M1到M2) 和基因表达变化.
在牛皮模型中评估了新型光疗的治疗疗效和安全性.

主要成果:

UCNP光疗调节了素3,抑制了亲炎性M1巨细胞,并促进了抗炎性M2巨细胞.
转录组分析显示,IL-23诱导的牛皮表型通过上调M2相关基因而逆转.
在没有光毒性的情况下,观察到牛皮样皮肤炎的显著改善.

结论:

在牛皮中,UCNP介导的光疗显示了将巨细胞从M1转换为M2表型的潜力.
这种新的方法为治疗牛皮皮炎提供了一个有希望的,更安全的替代方案.
对UCNP的进一步研究可能会导致慢性炎症性皮肤疾病的先进光疗策略.

关键词:

它们有IL-23和IL-23.巨细胞是一个巨细胞.照明疗法照明疗法照明疗法牛皮是一种牛皮.上升转换是一种上升转换.

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