照亮看不见的:心血管医学中的翻译分子成像
Yan Ma1, Naiyuan Sun2, Yan Fang1
1Cardiology Department and National Clinical Research Center for Geriatric Diseases, Chinese Military Medical School, The Second Medical Center, Chinese PLA General Hospital, Beijing (Y.M., Y.F., Y.W., F.C.).
Circulation research
|March 12, 2026
概括
分子成像提供了对心血管疾病过程的高级可视化,检测了传统方法错过的早期分子变化. 这种方法有助于风险分层和个性化治疗心脏病.
科学领域:
- 心血管医学 心血管医学
- 分子成像学分子成像学
- 生物医学工程 生物医学工程
背景情况:
- 心血管疾病是全球领先的健康问题,不良结果越来越多.
- 传统的成像技术对明显病理之前的亚临床分子变化缺乏灵敏度.
研究的目的:
- 审查用于心血管疾病的分子成像探针和平台.
- 评估它们在风险分层和治疗监测中的作用.
- 探索人工智能和多态学集成,用于精确的心血管医学.
主要方法:
- 对分子探针 (纳米粒子,抗体,) 进行针对目标特异性,药理动力学和临床用途的批判性评估.
- 对分子成像平台的审查 (核,MRI,CT,超声波,光声学).
- 在探测器开发和目标验证中讨论AI和multiomics.
主要成果:
- 分子成像可视化体内疾病过程,如炎症和代谢失调.
- 分子成像有助于评估动脉样硬化,粉症,心肌病和重塑.
- 人工智能和多组学加速了用于精密医学的探测器开发.
结论:
- 分子成像代表了心血管医学中的范式转变.
- 它可以实现机械上知情的,精确的心血管护理.
- 通过先进的分子探测器和人工智能集成,预计会有增强的诊断和治疗方法.
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