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一个深度的时间景观的植物cis-regulatory序列进化演变

Kirk R Amundson¹, Anat Hendelman^2,3, Danielle Ciren⁴

¹Department of Biology, University of Massachusetts, Amherst, MA, USA.

Science (New York, N.Y.)

|March 12, 2026

概括

科学家们发现了3000多个古老的cis-regulatory序列 (CNSs),这些序列早于开花植物,揭示了植物进化3亿年来保存的基因调节.

科学领域:

进化生物学是进化的生物学.
基因组学就是基因组学.
发育生物学是发展生物学.

背景情况:

保存的非编码序列 (CNSs) 对于基因调节至关重要,但由于快速序列进化和基因组变化,难以确定.
以前的方法很难在广的进化时间尺度和各种植物物种中发现中枢神经系统.

研究的目的:

开发和应用一种新的计算方法来发现古代的中枢神经系统及其相关基因在植物进化过程中.
研究保存的 cis-调节元素的进化动态和功能意义.

主要方法:

开发了温室算法,利用微合成和代对齐来绘制中枢神经系统基因关联.
分析了284个植物物种的基因组数据,涵盖了3亿年的多样化.
通过在HOMEOBOX基因附近突变的中枢神经系统进行实验验证.

主要成果:

确定了大约230万个中枢神经系统,其中包括3000多个古老的中枢神经系统.
发现古老的中枢神经系统在发育调节基因附近被显著丰富.
在HOMEOBOX基因附近的中枢神经系统的突变导致明显的发育表型.

结论:

中枢神经系统的顺序保持不变,尽管间距有所不同,基因组重组可以创建新的中枢神经系统基因链接.
古代的中枢神经系统在相似物中表现出优先保留,但可以丢失或演变为谱系特定的元素.
这项研究为发现古老的调节元素和理解它们在进化过程中的作用提供了一个强大的框架.

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