格利克拉提升了健康受过训练的个体的运动表现和肌肉力量的恢复:一个随机对照试验
Jocelito Bijoldo Martins1, Thiago Dipp1,2, Beatriz D Schaan3,4
1Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, RS, Brazil.
European journal of sport science
|March 12, 2026
概括
格利克拉改性释放 (MR) 增强了男性的力量炼表现和肌肉恢复. 然而,一些参与者经历过低血糖症,这表明与性能益处一起存在潜在风险.
科学领域:
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
- 运动科学 运动科学 运动科学
背景情况:
- 降血糖药物对运动表现的影响尚未完全理解.
- 格利克拉是一种硫氨基尿素,通常用于2型糖尿病.
研究的目的:
- 研究基克拉胺修饰释放 (MR) 对健康,力量训练的男性的运动表现和肌肉恢复的急性影响.
- 为了评估运动前使用gliclazide的安全性和有效性.
主要方法:
- 一个随机,双盲,安慰剂控制的交叉试验,涉及44名力量训练的男性.
- 参与者在连续三次力量炼 (长椅压力,) 之前8小时接受了gliclazide MR (90毫克) 或安慰剂.
- 评估结果包括总体积负荷 (VL),运动范围 (ROM),肌肉损伤标记 (CK-MM,LDH),炎症标记 (IL-6,TNF-α) 和主观恢复得分.
主要成果:
- 格利克拉显著提高了运动表现,在长椅压力中增加了23.3%的总体VL,在式运动中增加了23.2% (p < 0.001).
- 运动后24-48小时肌肉恢复得到改善,ROM缺陷,CK-MM,LDH,TNF-α,IL-6和肌肉疼痛显著减少.
- 在gliclazide组的7%的参与者中观察到低血糖事件.
结论:
- 在力量炼前8小时服用格利克拉 MR (90毫克) 显示出人体效能效应,改善健康男性的表现和肌肉恢复.
- 在评估gliclazide在身体活跃个体的使用时,应考虑低血糖的潜在风险.
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