子宫内膜异位症病变按年龄分布:一个国际多中心数据库研究
Jonathan Lewin1,2, Arvind Vashisht1,2, Dean Langan3
1Department of Gynaecology, University College London Hospital, London, UK.
Human reproduction (Oxford, England)
|March 12, 2026
概括
患有子宫内膜异位症的老年患者表现出更高的深层病变和卵巢内膜异位瘤的患病率,尽管这一趋势在30岁左右停滞不前. 表面性子宫内膜异位症随着年龄的增长而减少.
科学领域:
- 妇科 妇科 妇科 妇科
- 手术病理学手术病理学
- 流行病学 流行病学
背景情况:
- 子宫内膜异位症的自然史和原因尚未完全理解,关于疾病进展,自发回归和稳定性的证据各不相同.
- 现有的研究提出了关于子宫内膜异位症随着患者年龄的演变的相互矛盾的数据.
研究的目的:
- 为了研究子宫内膜异位症病变的频率和解剖位置如何随着患者年龄而变化.
- 分析患者年龄与腹腔镜检查期间观察到的不同类型子宫内膜异位病变的患病率之间的关系.
主要方法:
- 通过从前性收集的外科注册表中收集的数据进行了横截面分析.
- 分析了来自7个国家的104个认可的子宫内膜异位症中心的14670例病例的数据,涵盖2009-2021年10-55岁的年龄段.
- 使用后勤回归模型来评估年龄和病变患病率之间的关联,并对先前的子宫内膜异位症手术进行调整.
主要成果:
- 表面性子宫内膜异位症的患病率随着年龄的增长线性下降 (每年3%).
- 肠道,深侧壁和子宫神经内膜异位症的患病率随着年龄的增长而增加,直到30多岁的早期,深膀疾病在28岁左右达到顶峰.
- 卵巢内膜瘤的患病率增加到40.9岁,而受影响部位的总数增加到32.8岁.
结论:
- 与年轻患者相比,老年患者往往有更深层次的子宫内膜异位症病变和卵巢内膜瘤.
- 表面性子宫内膜异位症的患病率随着年龄的增长而降低.
- 研究结果表明,子宫内膜异位症病变的分布和类型存在与年龄相关的模式.
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