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Updated: Jul 14, 2026

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复合Kushen注射通过调节Piezo1-介导的NF-κB/NLRP3通路来改善M1巨细胞极化和辐射诱导的大肠炎

Xin Sun1, Zheng Li2, Shangfei Luo1

  • 1Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road Changqing District, Ji'nan, Shandong 250355, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology
|March 12, 2026
PubMed
概括

复合Kushen注射 (CKI) 通过抑制巨细胞中的Piezo1激活来预防辐射诱导性结肠炎 (RIC). 这种Piezo1-NF-κB/NLRP3通路的调节减少了炎症并改善了RIC的结果.

关键词:
复合物库申注射剂 复合物库申注射剂炎症 炎症是一种炎症.巨细胞是一个巨细胞.这是一个Piezo1.辐射诱导的大肠炎

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...