在社区居住的老年人中,在痴呆症诊断之前重复测量身体活动:一项纵向研究
Shahram Oveisgharan1, Jingyun Yang1, Tianhao Wang1
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
The lancet. Healthy longevity
|March 12, 2026
概括
定期体育活动可以保护老年人免受痴呆. 然而,它的益处在诊断前的几年似乎最显著,这表明时间对于预防痴呆症至关重要.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 以前的研究将老年人的单一体育活动措施与痴呆症风险联系起来.
- 重复体育活动对痴呆症发病率的影响需要进一步调查.
研究的目的:
- 检查身体活动的重复测量如何影响与事件痴呆症的关联.
- 为了确定身体活动对痴呆症的保护作用是否随着时间的推移而变化.
主要方法:
- 利用了来自Rush Memory and Aging Project (MAP) 的数据,这是一项以社区为基础的纵向研究.
- 使用联合建模 (线性混合效应和考克斯模型) 来进行前性分析.
- 应用了时间变化的效应模型,以追溯分析痴呆症诊断前的身体活动.
主要成果:
- 包括972名老年人,每两年经常进行体力活动测量.
- 发现身体活动和发病痴呆症 (HR 0.78) 之间存在关联,模型准确性更强,更接近诊断.
- 6年后的体力活动显示出显著的保护性关联 (HR 0.55),与7年后的基线活动不同.
结论:
- 身体活动是一种潜在的可修改的预防老年痴呆的保护因素.
- 重复测量表明,与痴呆症发病相关的体育活动益处的时间需要进一步研究.
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